Renelle Lim, M.D., FACS

Contact Information

Office Address: 1617 S. Tuttle Street, 3rd Floor, Sarasota, FL 34239

Languages

English (native), Creole (fluent), Spanish (proficient)

Education

08/02 – BS City University of New York, Brooklyn College – Biology 10/06
– MD State University of New York Downstate Medical Schoo

Postgraduate Education and Training

07/10 – 06/11 Intern in Medicine, Mount Sinai Elmhurst, Elmhurst, NY
07/11 – 06/14 Ophthalmology Residency, State University of New York Downstate Medical Center, Brooklyn,
NY
07/14 – 06/16 Ocular Oncology Fellowship, Wills Eye Hospital, Philadelphia, PA
07/16 – 06/17 Oculoplastic & Orbital Surgery Fellowship, Wills Eye Hospital, Philadelphia, PA

Employment

08/22 – present Institute of Dermatology & Oculoplastic Surgery 08/17
– 07/22 Yale University School of Medicine, New Haven, CT
Director of the Ocular Oncology Service, Assistant Professor Oculoplastic Surgeon

Medial Licenses

Florida
Connecticut

Board Certification

Ophthalmology 10/18/15

Professional and Scientific Committees:

1. Yale Ophthalmology Society (07/17– 07/2022)
2. American Academy of Ophthalmology, ONE Network oncology and pathology editorial committee (05/17–
   2021)
3. American Academy of Ophthalmology (Member 2011–present) American
   Association for Cancer Research (Member 2014–present)
4. American Association of Ophthalmic Oncologists and Pathologists (11/17 – present) Yale
5. Cancer Center (01/2018 – 07/2022)
6. North American Society of Academic Orbital Surgeons (2/2019 – present) Minority
7. Ophthalmology Mentoring (7/17 – present)
8. Yale Cancer Center, Diversity & Inclusion (2020– 2022)

Honors and Awards

1. 07/02 – 06/06 Presidential Scholar, CUNY Brooklyn College
2. 07/02 – 06/06 Dean's Honor List, City University of New York, CUNY Brooklyn College 08/06 –
3. 06/10 Peter Vallone Scholarship in Recognition of Academic Excellence, Downstate Medical
   Center
4. 10/06 Endowed Honor Scholarship for Academic Excellence, Downstate Medical Center
5. 2010 Medical School Alumni Association Scholarship, Downstate Medical Center
6. 2010 Excellence in Ophthalmology Award, Downstate Medical Center
7. 2011 Outstanding First Year Resident Award, Mount Sinai Elmhurst
8. 2013 Doctorʼs Award – In Recognition of Dedication & Service, Downstate Medical Center
9. 2019 International Society of Ocular Oncology – Best Paper, Las Angeles, CA
10. 2021 American Academy of Ophthalmology Achievement Award

Past Grants

Agency: National Institute of Health
Title: The Use of Plasma Cell–Free DNA Methylomes as a Surrogate Marker of Micro–metastasis in
Melanoma P.I.: Renelle Lim, MD
Percent effort: 50%
Direct costs per year: $ 31,292
Total costs for project period: $283,149
Project period: 9/1/2021 – 07/15/2022

Agency: Yale Career Program Enhancement Award
Title: DNA Methylation Signature for Conjunctival Melanoma P.I.:
Renelle Lim, MD
Percent effort: 1%
Direct costs per year: $ 14,000
Total costs for project period: $20,000
Project period: 9/1/2020 – 8/31/2021

Agency: Connecticut Lions Eye Research Foundation
Title: DNA Methylation Signature for Conjunctival Melanoma P.I.:
Renelle Lim, MD
Percent effort: 1%
Direct costs per year: $ 115,000
Total costs for project period: $135,338
Project period: 5/1/2020 – 4/30/2022

Agency: Tumori Foundation Grant
Title: Underpinnings of response to immunotherapy in uveal melanoma
P.I.: Renelle Lim, MD
Percent effort: 1%
Direct costs per year: $ 80,000
Total costs for project period: $100,000
Project period: 10/2018 – 6/2021

Peer–Reviewed Publications

1. Miguez S, Lee RY, Chan AX, Demkowicz PC, Jones BSCL, Long CP, Abramson DH, Bosenberg M, Sznol M, Kluger H, Goldbaum MH, Francis JH, Pointdujour–Lim R, Bakhoum MF. Validation of the Prognostic Usefulness of the Gene Expression Profiling Test in Patients with Uveal Melanoma. Ophthalmology. 2023 Feb 4:S0161–6420(23)00064–7. doi: 10.1016/j.ophtha.2023.01.020. Epub ahead of print. PMID: 36739981.
2. Dhodapkar R, Heng J, Zhu J, Lee Y, Habib L, Sinard J, Pointdujour– Lim R. NK/T– cell lymphoma with orbital involvement: a case report and systematic review of the literature. OPRS 2022 – Accepted
3. Heng JS, Perzia BM, Sinard JH, Pointdujour–Lim R. Local recurrence of uveal melanoma and concomitant brain metastases associated with an activating telomerase promoter mutation seven years after secondary enucleation. Am J Ophthalmol Case Rep. 2022 Jun 1;27:101607.
4. Wang k, Zhu J, Pointdujour–Lim R. Incidental Eyelid Ixodes Scapularis. Journal of Case Reports and Images in Ophthalmology. 2022 Accepted
5. Abdel–Aty A, Jin A, Manes RP, Pointdujour–Lim R. Dacryocystitis in a Patient with Samterʼs. Oman Journal. Accepted
6. Steren B, Burtness B, Bhatia A, Demirci H, Shinder R, Yoo D, Tse B, Pointdujour–Lim R. Cemiplimab for Orbital Squamous Cell Carcinoma in 11 Cases. Ophthalmic Plast Reconstr Surg. 2022 Sep–Oct 01;38(5):496–502.
7. Heng, J, Kim J, Jones K et al. Pointdujour–Lim R. Autoimmune retinopathy with associated anti–retinal antibodies as a potential immune–related adverse event associated with immunotherapy in patients with advanced cutaneous melanoma: case series and systematic review. BMJ Open Ophthalmology Accepted
8. Abdel–Aty A, Linderman W.L, Kombo N, Sinard J, Pointdujour–Lim R. Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review. Ocular Oncology and Pathology Accepted.
9. Hong CS, Fliney G, Fisayo A, An Y, Gopal PP, Omuro A, Pointdujour–Lim R, Erson–Omay EZ, Omay SB. Genetic characterization of an aggressive optic nerve pilocytic glioma. Brain Tumor Pathol. 2021 Jan;38(1):59–63.
10. Fliney GD, Megalla M, Pointdujour–Lim R, Howard MA. Inferior Rectus and Inferior Oblique Muscle Transections with Medial Rectus Muscle Partial Avulsion, following Metal Hook Injury. J Binocul Vis Ocul Motil. 2021.
11. Park MM, Ahmed OM, Ng JD, Vloka CN, Dansdill D, Shinder R, Sniegowski M, Richani K, Lucarelli MJ, van Landingham SW, Pointdujour–Lim R. Simultaneous Orbital and Intracranial Abscesses in 17 Cases. Ophthalmic Plast Reconstr Surg. 2020 Jun 18.
12. Ahmed O, Ma A, Ahmed T, Pointdujour–Lim R. Epidemiology, outcomes and prognostic factors of orbital lymphoma in the United States. Accepted for Publication – Orbit 2019.
13. Vagge A, Schnall B, Levin A, Traverso CE, Pointdujour–Lim R, Shields C. Visual improvement in amblyopic eye following treatment–induced vision loss in dominant eye with uveal melanoma. British Journal of Ophthalmology 2019. [E pub ahead of print]
14. Kim J, Materin MA, Sznol M, Kluger H, Weiss S, Chow J, Stoessel K, Kombo N, Del Priore L, Pointdujour–Lim R. Ophthalmic Immune–Related Adverse Events of Immunotherapy: A Single–Site Case Series. Ophthalmology. 2019 in press
15. Wong A, Kim J, Lu A, Pointdujour–Lim R. Rapidly Growing Choroidal Chondrosarcoma. Ocular Oncology and Pathology 2018. In press
16. Chan L, Megalla M, Kim JM, Pointdujour–Lim R. Spinal Ewing Sarcoma Metastatic to Bilateral Orbits. Ophthalmic Plast Reconstr Surg. 2018 Nov/Dec;34(6):e206–e208.
17. Shah SN, Kogachi K, Correa ZM, Schefler AC, Aronow ME, Callejo SA, Cebulla CM, Day–Ghafoori S, Francis JH, Lally S, McCannel TA, Paton KE, Phan IT, Pointdujour–Lim R, Ramasubramanian A, Rath P, Shields CL, Skalet AH, Wells JR, Jennelle RL, Berry JL. Trends in Radiation Practices for Female Ocular Oncologists in North America: A Collaborative Study of the International Society of Ocular Oncology. Ocul Oncol Pathol. 2019 Jan;5(1):54–59.
18. Liu W, Kim J, Young B, Pointdujour–Lim R. A Novel Eye Plaque Design for Brachytherapy of Iris and Ciliary Body Melanoma and Its First Clinical Application 2018. Ocular oncology and pathology 2018. In press
19.  Li E, Distefano A, Sinard J, Wong A, Pointdujour–Lim R. Epithelial–Myoepithelial Carcinoma Presenting as a Pseudo Veno–Lymphatic Malformation. Ophthalmic Plast Reconstr Surg. 2018 Sep/Oct;34(5):e157–e160.
20. Kim JM, Megalla M, Howard M, Sinard J, Pointdujour–Lim R. Orbital cellulitis with choroidal detachment following strabismus surgery in an adult. J AAPOS. 2018;22(6):477–480.
21. Turkoglu E, Pointdujour–Lim R, Mashayekhi A, Shields C. Photodynamic Therapy as Primary Treatment for Small Choroidal Melanoma. Retina 2018 [Epub ahead of print] PubMed PMID: 29659412.
22. Verter E, Yang A, Pointdujour–Lim, R. Leukemic Optic Nerve Infiltration Responds to Radiation and Blinatumomab. Ophthalmology. 2018 May;125(5):746.
23. Surakiatchanukul T, Sioufi K, Pointdujour–Lim R, Eagle RC, Shields JA, Shields CL. Caruncular Oncocytoma Mimicking Malignant Melanoma. Ocul Oncol Pathol. 2017 Nov;3(4):320–323.
24. Pointdujour–Lim R, Lally SE, Shields J, Eagle RC, Shields C. Orbital Schwannoma: Radiographic and Histopathologic Correlation in 15 cases. Ophthalmic Plast Reconstr Surg. 2018;34(2):162–167.
25. Pointdujour–Lim R, Say EA, Shields C. Juvenile X–linked retinoschisis presenting as juxtapapillary retinal fold mimicking combined hamartoma of the retina and retinal pigment epithelium. J AAPOS. 2017m Apr;21(2):170–172.
26. Rao R, Pointdujour–Lim R, Shields C. Multifocal choroidal melanoma in a patient with germline BRCA Associated Protein Mutation. Retin Cases Brief Rep. 2018 Winter;12(1):1–4.
27. Pointdujour–Lim R, Marous MR, Satija CE, Douglass AM, Eagle RC Jr, Shields JA, Shields CL. Cutaneous Horn of the Eyelid in 13 Cases. Ophthal Plast Reconstr Surg. 2017 July;33(4):233–236.
28. Barna LE, Pointdujour–Lim R, Shields CL. String of Pearls: Macroaneurysms in Coats Disease. J Pediatr Ophthalmol Strabismus. 2017 Jul 1;54(4):256.
29. Anderson HJ, Pointdujour–Lim R, Shields CL. Treatments for Retinoblastoma Then and Now. JAMA Ophthalmol 2017; 12;135(1):e164652.
30. Temnogorod J, Pointdujour–Lim R, Mancini R, Chang SH, Allen RC, Shinder R. Acute Orbital Syndrome in Herpes Zoster Ophthalmicus: Clinical Features of 7 Cases. Ophthal Plast Reconstr Surg. 2017 May/Jun;33(3):173–177.
31. Pointdujour–Lim R, Mashayekhi A, Shields J, Shields C. Photodynamic therapy for choroidal nevus with subfoveal fluid in 15 cases. Retina. 2017 Apr;37(4):718–723.
32. Deaner JD, Pointdujour–Lim R, Say EA, Shields CL. Unrelenting Ocular Pain as a Masquerading Symptom of Occult Choroidal Metastasis. Ocul Oncol Pathol. 2017 Jan;3(1):56–59.
33. Mashayekhi A, Lim RP, Shields CL, Eagle RC Jr, Shields JA. Extraocular extension of ciliochoroidal melanoma after trans–scleral fine needle aspiration biopsy. Retin Cases Brief Rep. 2016 Summer;10(3):289–92.
34. Wilson ME, Pointdujour–Lim R, Lally S, Shields CL, Rabinowitz MP. Acute Charles Bonnet Syndrome following Hughes procedure. Orbit. 2016 Oct;35(5):292–4.
35. Shields JA, Pointdujour–Lim R, Lally SE, Eagle RC Jr, Shields CL. Malignant Melanoma Presenting as Pedunculated Lesion of the Caruncle. JAMA Ophthalmol. 2016 Apr;134(4):464–6.
36. Samara WA, Pointdujour–Lim R, Say EA, Shields CL. Foveal microanatomy documented by SD–OCT following treatment of advanced retinoblastoma. JAAPOS. 2015 Aug;19(4):368–72.
37. Tang SX, Lim RP, Al–Dahmash S, Blaydon SM, Cho R, Choe CH, Conner MA, Durairaj VD, Eckstein LA, Hayek B, Langer PD, Lelli GJ, Mancini R, Rabinovich A, Servat J, Shore JW, Sokol JA, Tsirbas A, Vagefi MR, Wladis EJ, Wu AY, Shields JA, Shields C, Shinder R. Bilateral Lacrimal Gland Disease – Clinical Features of 97 Cases. Ophthalmology 2014 Oct; 121(10):2040–6.
38. Dua P, Pointdujour R, Reich I, Lazzaro DR, Shinder R. Orbital vicarious menstruation. Ophthal Plast Reconstr Surg. 2014 Mar–Apr;30(2):e35–7.
39. Elmann S, Pointdujour R, Blaydon S, Nakra T, Connor M, Mukhopadhyay C, Levin F, Schwarcz R,n Shepler T, Shore JW, Wladis EJ, Shinder R. Periocular Abscesses Following Brow Epilation. Ophthal Plast Reconstr Surg. 2012 Nov;28(6):434–7.
40. Pointdujour R, Shinder R. Lacrimal gland pleomorphic adenoma. Ophthalmology. 2012 Jun;119(6):1293–4; author reply 1294.
41. Gutman J, Pointdujour R, Shinder R. Response: Complications of blepharoptosis surgery. Arch Ophthal. 2012 May; 130(5):666; author reply.
42. Mostafavi D, Pointdujour R, Gutman J, Shinder R. Isolated Lateral Rectus Muscle Involvement as a Presenting Sign of Euthyroid Graves Disease. J AAPOS. 2012 Apr; 16(2):216–7; author reply 217.
43. Pointdujour R, Gutman J, Shinder R. Response: Quality of Life in a German Graves Orbitopathy Population. Am J Ophthalmol. 2012 Feb;153(2):380–1; author reply.
44. Pointdujour R, Ahmad H, Liu P, Lazzaro DR. Beta–Blockade Affects Simulator Scores. Ophthalmology. 2011 Sep;118(9):1893.

Non–Peer Reviewed Publications

1. Sioufi K, Pointdujour–Lim R, Shields C. Uveal Melanoma in an African American. Retina Today. 2015
2. Badami A, Pointdujour–Lim R, Shields C. Photodynamic Therapy for Choroidal Metastasis from Renal Cell Carcinoma. Retina Today. 2014
3. Singh S, Pointdujour–Lim R, Shields C. Stunning visualization of fetal hyaloid artery. Retina Today. 2014
4. Pointdujour–Lim R, Say EA, Shields C. Vasoproliferative Tumor With Complete Response to Cryotherapy–
   Nine Year Follow Up. Retina Today. 2014

Abstracts and/or Proceedings:

1. Lu A, Pointdujour-Lim R. Correlation of clinical features and treatment outcomes of primary ocular-adnexal mantle cell lymphoma based on the National Cancer Database. American Academy of Ophthalmology: Chicago, October 2018. Poster presentation
2. Kim J, Materin M, Kombo N, Stoessle K, Del Priore L, Chow J, Pointdujour-Lim R. Immune-related ocular side effects from nivolumav with/ without ipilimumab – a single site series. Association for Research in Vision and Ophthalmology: Honolulu, Hawaii April Poster presentation
3. Pointdujour-Lim R, Shields C, Khoo C, Say EAT. Rescue Intra-Arterial Chemotherapy Following Retinoblastoma Recurrence After Initial Intra-Arterial Chemotherapy. Association for Research in Vision and Ophthalmology Annual Meeting: Denver, May 2015. Poster Presentation
4. Samara W, Pointdujour-Lim R, Mashayekhi A, Shields J, Shields C. Photodynamic Therapy for Symptomatic Choroidal Nevi in 23 Cases. Association for Research in Vision and Ophthalmology Annual Meeting: Denver, May 2015. Poster Presentation
5. Farber N, Shao A, Pointdujour-Lim R, Nakra T, Shinder R. Metastatic Melanoma of the Lateral Rectus Misdiagnosed as Idiopathic Orbital Inflammation. American Society of Ophthalmic Plastic & Reconstructive Fall Symposium; Chicago, IL. October 2014. Podium Presentation.
6. Pointdujour R, Lazzaro D. Sjogrens Syndrome & Scleromalcia After Pterygium Excision. Current Concepts in Atlantic City, NJ. January 2013. Podium Presentation.
7. Pointdujour R, Temnogorod J, Kartvelishvili A, Mancini R, Chang SH, Shah S, Esmaeli B, Shinder R. Acute Orbital Syndrome in Herpes Zoster Ophthalmicus. American Society of Ophthalmic Plastic & Reconstructive Fall Symposium; Chicago, IL. November 2012. Podium Presentation.
8. Pointdujour R, Reich I, Nakra T, Gindina S, Shinder R. Vicarious Menstruation in the Orbit of a Young American Society of Ophthalmic Plastic & Reconstructive Surgery. Fall Symposium; Chicago, IL. November 2012.
9. Pointdujour R, Gutman J, Calderon C, Rizzuti A, Langer P, Shinder R. Intraoperative Mitomycin C to Retard Future Cicatrix Formation During Severe Cicatricial Lid Retraction Repair. American Society of Ophthalmic Plastic & Reconstructive Fall Symposium; Chicago, IL. November 2012.
10. Pointdujour R, Gutman J, Calderon C, Langer P, Shinder R. Intraoperative Mitomycin C To Retard Future Cicatrix Formation During Severe Cicatricial Lid Retraction Repair. Association for Research in Vision and Ophthalmology Annual Meeting: Fort Lauderdale, May 2012.
11. Spindle J, Mostafavi D, Pointdujour R, Moss J, Rand D, Dweck M, Shelper T, Shore J, Shinder R. Orbital Floor Fracture with Entrapment: A Common Cause of Clinical & Radiographic Error. Association for Research in Vision and Ophthalmology Annual Meeting: Fort Lauderdale, May 2012.
12. Rand D, Butts S, Nath J, Gorski M, Pointdujour R, Shinder R. Frontoethmoidal Sinus Mucocele Associated with Osteoma. Association for Research in Vision and Ophthalmology Annual meeting: Fort Lauderdale, FL. May
13. Schwartzstein H, Shields C, Kligman B, Alterman M, Farah A, Malaviya L, Desai V, Dellacava E, Perlmutter D, Hundle R, Pointdujour R, Warrier N, Miller R, Sohrab M, Shankar R, Mandalaywala M, Say E, Mashayekhi A, Shields Metastasis Following Plaque Radiotherapy of Small Posterior Uveal Melanoma in 1524 Cases. NYSOMS Abstract Proceedings. Wills Eye Institute. March 2011.

14. Pointdujour R, Jean-Louis G, Zizi F Singh M, Dweck M, Lazzaro D. Influence of Visual Impairment and Depression on Rest-Activity Cycles. The 2010 Association for Research in Vision and Ophthalmology Annual meeting: Fort Lauderdale, April 2010.

15. Singh M, Jean-Louis G, Zizi F, Pointdujour R, Dweck M, Lazzaro DR. Vision Problems and Insomnia Symptoms Among Older Russians. The 2010 Association for Research in Vision and Ophthalmology. Fort Lauderdale, April 2010.
16. Ahmad H, Pointdujour R, Smith E, Lazzaro DR. The Effect of Caffeine and Beta Blockade on Anterior Segment Surgical Performance using the EYESi VRMagic Anti-Tremor, Anti-Forceps, and Capsulorhexis Surgical Simulator Modules. The 2009 Joint Meeting of the American Academy of Ophthalmology with the Pan-American Association of Ophthalmology; San Francisco, October 2009.
17. Lazzaro DR, Li Y, Pinzon-Duarte GA, Lee A, Pointdujour R, Chamnongvongse P, Libby R, Brunken Anterior Segment Disruptions in Laminin and Netrin Null Mice- Pierson Syndrome. The 2009 Association for Research in Vision and Ophthalmology. Fort Lauderdale, FL. March 2009.
18. Pointdujour-Lim, American Academy of Ophthalmology. Orbital Tumors. Virtual 2021.
19. Pointdujour-Lim, R. American Academy of Ophthalmology. Orbital Imaging Course. New Orleans, LA. Nov 2021
20. Pointujour-Lim Ocular Surface Neoplasia. NASAOS. Houston, TX. March 2022
21. Heng J, Brittany P, Pointdujour R Telomerase gene promoter (TERT) mutation in recurrent uveal melanoma after secondary enucleation revealed by targeted next-generation sequencing. ARVO Abstract # 2022 ARVO Annual Meeting. Denver, CO
22. Heng J, Brittany P, Pointdujour R Telomerase gene promoter (TERT) mutation in recurrent uveal melanoma after secondary enucleation revealed by targeted next-generation sequencing. ISOO 2022 Congress: Poster Session P2 Uveal Abstract #4189 Leiden, The Netherlands